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Novel selective inhibitor of Leishmania (Leishmania) amazonensis arginase
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Three Novel triazolopyrimidinehavebeensynthesizedand evaluated as arginase inhibitors Compound 30 has a CF3 group in the 2‐position (R1) and a hydrazinecarbothioamide in the 7‐position (R3) Compound 30 showed an IC50 of 16.5 ± 0.5 and is a noncompetitive inhibitors (Ki = Ki’) with Ki = 17 ± 1 μM
Source: Chemical Biology and Drug Design - April 1, 2015 Category: Biology Authors: Edson R. da Silva, Nubia Boechat, Luiz C. S. Pinheiro, Monica M. Bastos, Carolina C. P. Costa, Juliana C. Bartholomeu, Talita H. da Costa Tags: Research Article Source Type: research
New insights into the mechanistic action of methyldehydrodieugenol B towards Leishmania (L.) infantum via a multiplatform based untargeted metabolomics approach
ConclusionThese results contributed to elucidate the broad action of methyldehydrodieugenol B against Leishmania, paving the way in the search of novel alternative therapies.
Source: Metabolomics - March 13, 2017 Category: Biology Source Type: research
Molecular Detection of Leishmania DNA in Wild-Caught Phlebotomine Sand Flies (Diptera: Psychodidae) From a Cave in the State of Minas Gerais, Brazil
Leishmania spp. are distributed throughout the world, and different species are associated with varying degrees of disease severity. In Brazil, Leishmania transmission involves several species of phlebotomine sand flies that are closely associated with different parasites and reservoirs, and thereby giving rise to different transmission cycles. Infection occurs during the bloodmeals of sand flies obtained from a variety of wild and domestic animals, and sometimes from humans. The present study focused on detection of Leishmania DNA in phlebotomine sand flies from a cave in the state of Minas Gerais. Detection of Leishmania...
Source: Journal of Medical Entomology - January 11, 2017 Category: Biology Authors: Carvalho, G. M. L., Brazil, R. P., Rego, F. D., Ramos, M. C. N. F., Zenobio, A. P. L. A., Andrade Filho, J. D. Tags: Vector/Pathogen/Host Interaction, Transmission Source Type: research
Physalis angulata induces death of promastigotes and amastigotes of Leishmania (Leishmania) amazonensis via the generation of reactive oxygen species
Publication date: March 2016 Source:Micron, Volume 82 Author(s): B.J.M Da Silva, R.R.P. Da Silva, A.P.D. Rodrigues, L.H.S. Farias, J.L.M. Do Nascimento, E.O. Silva Leishmaniasis are a neglected group of emerging diseases that have been found in 98 countries and are caused by protozoa of the genus Leishmania. The therapy for leishmaniasis causes several side effects and leads to drug-resistant strains. Natural products from plants have exhibited activities against Leishmania in various experimental models. Physalis angulata is a widely used plant in popular medicine, and in the literature it has well-documented leis...
Source: Micron - January 12, 2016 Category: Biology Source Type: research
Synthesis and Biological Evaluation of Tricyclic Guanidine Analogues of Batzelladine K for Antimalarial, Antileishmanial, Antibacterial, Antifungal, and Anti‐HIV Activities
Fifty analogues of batzelladine K were synthesized and evaluated for in vitro antimalarial (Plasmodium falciparum), antileishmanial (Leishmania donovani), antimicrobial (panel of bacteria and fungi), antiviral (HIV‐1) activities. Analogues 14h and 20l exhibited potential antimalarial activity against chloroquine‐sensitive D6 strain with IC50 1.25 and 0.88 μm and chloroquine‐resistant W2 strain with IC50 1.64 and 1.07 μm, respectively. Analogues 12c and 14c having nonyl substitution showed the most potent antileishmanial activity with IC50 2.39 and 2.78 μm and IC90 11.27 and 12.76 μm, respectively. Three a...
Source: Chemical Biology and Drug Design - March 28, 2013 Category: Biology Authors: Nafees Ahmed, Keyur G. Brahmbhatt, Shabana I. Khan, Melissa Jacob, Babu L. Tekwani, Sudeep Sabde, Debashis Mitra, Inder P. Singh, Ikhlas A. Khan, Kamlesh K. Bhutani Tags: Research Article Source Type: research
Excreted Leishmania peruviana and Leishmania amazonensis iron superoxide dismutase purification: Specific antibodies detection in Colombian patients with cutaneous leishmaniasis.
Abstract
Leishmania sp. survival in the vertebrate host depends on the host macrophage immune response as well on the parasite's defence against free radicals. Iron superoxide dismutase (Fe-SOD) is a key antioxidant enzyme which contributes to radical superoxide dismutation, preventing the disease to surge and propagate itself. Leishmania sp. has different Fe-SOD isoforms, one of which (Fe-SODe) is excreted into the medium and, being highly immunogenic, can be considered a very good molecular marker. In this work, we purified the Fe-SOD enzymes excreted by L. peruviana and L. amazonensis and studied them as antige...
Source: Free Radical Biology and Medicine - January 14, 2014 Category: Biology Authors: Stefania Longoni S, Marín C, Sanchez-Moreno M Tags: Free Radic Biol Med Source Type: research
Novel inhibitors of ornithine decarboxylase of Leishmania parasite (LdODC): The parasite resists LdODC inhibition by over‐expression of spermidine synthase
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Novel inhibitors of ornithine decarboxylase of Leishmania donovani are identified. Effect of inhibitors on the parasite survival was studied. Leishmania resists these LdODC inhibitors by over‐expression of spermidine synthase mRNA
Source: Chemical Biology and Drug Design - September 1, 2015 Category: Biology Authors: Mousumi Das, Shalini Singh, Vikash Kumar Dubey Tags: Research Article Source Type: research
Boundary behaviours of Leishmania mexicana: a hydrodynamic simulation study
Publication date: Available online 20 November 2018Source: Journal of Theoretical BiologyAuthor(s): Benjamin J. Walker, Richard J. Wheeler, Kenta Ishimoto, Eamonn A. GaffneyAbstractIt is well established that the parasites of the genus Leishmania exhibit complex surface interactions with the sandfly vector midgut epithelium, but no prior study has considered the details of their hydrodynamics. Here, the boundary behaviours of motile Leishmania mexicana promastigotes are explored in a computational study using the boundary element method, with a model flagellar beating pattern that has been identified from digital videomicr...
Source: Journal of Theoretical Biology - November 21, 2018 Category: Biology Source Type: research
Genome-Wide Stochastic Adaptive DNA Amplification at Direct and Inverted DNA Repeats in the Parasite Leishmania
by Jean-Michel Ubeda, Frédéric Raymond, Angana Mukherjee, Marie Plourde, Hélène Gingras, Gaétan Roy, Andréanne Lapointe, Philippe Leprohon, Barbara Papadopoulou, Jacques Corbeil, Marc Ouellette
Gene amplification of specific loci has been described in all kingdoms of life. In the protozoan parasite Leishmania, the product of amplification is usually part of extrachromosomal circular or linear amplicons that are formed at the level of direct or inverted repeated sequences. A bioinformatics screen revealed that repeated sequences are widely distributed in the Leishmania genome and the repeats are chromosome-specific, ...
Source: PLoS Biology: Archived Table of Contents - May 20, 2014 Category: Biology Authors: Jean-Michel Ubeda et al. Source Type: research
PEGylated silver doped zinc oxide nanoparticles as novel photosensitizers for Photodynamic therapy against Leishmania.
We describe daylight responsive silver (Ag) doped semiconductor nanoparticles of zinc oxide (DSNs) for the Photodynamic Therapy (PDT) against Leishmania. The developed materials were characterized by X-Ray Diffraction analysis (XRD), Rutherford Back Scattering (RBS), Diffused Reflectance Spectroscopy (DRS) and band-gap analysis. The Ag doped semiconductor nanoparticles of zinc oxide were PEGylated to enhance their biocompatibility. The DSNs demonstrated effective daylight response in the PDT of Leishmania protozoans, through the generation of reactive oxygen species (ROS) with a quantum yield of 0.13 by non-doped zinc oxid...
Source: Free Radical Biology and Medicine - September 26, 2014 Category: Biology Authors: Nadhman A, Nazir S, Ihsanullah Khan M, Arooj S, Bakhtiar M, Shahnaz G, Yasinzai M Tags: Free Radic Biol Med Source Type: research
Detection of Leishmania amazonensis and Leishmania braziliensis in Culicoides (Diptera, Ceratopogonidae) in an endemic area of cutaneous leishmaniasis in the Brazilian Amazonia
ABSTRACT
Biting midges in the genus Culicoides act as vectors of arboviruses throughout the world and as vectors of filariasis in Latin America, the Caribbean, and parts of Africa. Although Culicoides spp. are currently not considered to be vectors of Leishmania protozoa, the high abundance of biting midges in areas with active cutaneous leishmaniasis transmission points to the possibility of Culicoides infection by these pathogens. We used PCR to test captured Culicoides species for natural infection with Leishmania spp. We tested 450 Culicoides females, divided into 30 pools of 15 individuals each, as follows: nine pools...
Source: Journal of Vector Ecology - November 16, 2016 Category: Biology Authors: Jos é Manuel Macário Rebêlo, Bruno Leite Rodrigues, Maria da Conceição Abreu Bandeira, Jorge Luiz Pinto Moraes, Raquel Silva Fonteles, Silma Regina Ferreira Pereira Tags: Original Articles Source Type: research
Construction and Characterization of HIV-1 env-Pseudoviruses of the Recombinant Form CRF63_02A and Subtype A6
HIV-1env-pseudoviruses are a useful tool in the search for antiviral drugs (entry inhibitors) and evaluation of the efficacy of HIV-1 vaccines. Given the high genetic variability of HIV-1, it is necessary to regularly update the panels of pseudoviruses in accordance with the emergence of new strains. Based on genetic variants of HIV-1 circulating in the regions of the Siberian Federal District, 13 HIV-1env-pseudoviruses of recombinant form CRF63_02A and subtype A6 were obtained. Most pseudoviruses have been shown to be sensitive to neutralization by bnAbs VRC01, PGT126, and 10E8, moderately sensitive to bnAbs PG9 and 4E10,...
Source: Bulletin of Experimental Biology and Medicine - May 2, 2022 Category: Biology Source Type: research
Swarna Bhasma Induces Antigen-Presenting Abilities of Macrophages and Helps Antigen Experienced CD4 < sup > + < /sup > T Cells to Acquire Th1 Phenotypes Against Leishmania donovani Antigens
Biol Trace Elem Res. 2023 Apr 24. doi: 10.1007/s12011-023-03659-3. Online ahead of print.ABSTRACTIn leishmaniasis, the protective immunity is largely mediated by proinflammatory cytokine producing abilities of T cells and an efficient parasite killing by phagocytic cells. Notwithstanding a substantial progress that has been made during last decades, the mechanisms or factors involved in establishing protective immunity against Leishmania are not identified. In ancient Indian literature, metallic "bhasma," particularly that of "swarna" or gold (fine gold particles), is indicated as one of the most prominent metal-based ther...
Source: Biological Trace Element Research - April 24, 2023 Category: Biology Authors: Shashi Saini Anshul Anand Abhishek Singh Baishakhi Mahapatra Shruti Sirohi Samer Singh Rakesh K Singh Source Type: research
Discovery of Synthetic Leishmania Inhibitors by Screening of a 2‐Arylbenzothiophene Library
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The screening of an estrogen receptor modulator related library of compounds allowed the identification of benzothiophenes as a new scaffold with antileishmanial properties. Three compounds devoid of estrogen receptor interaction were identified with increased potency against the parasite. Structure‐activity data for the synthetic benzothiophenes evaluated in this study indicates that optimal antileishmanial potency is dependent on the presence of two basic side chains.
Source: Chemical Biology and Drug Design - October 7, 2013 Category: Biology Authors: Vivian I. Bonano, Jenicer K.U. Yokoyama‐Yasunaka, Danilo C. Miguel, Scott A. Jones, Jeffrey A. Dodge, Silvia R. B. Uliana Tags: Research Article Source Type: research
